Seeking Health SAMe (S Adenosyl L Methionine) 250mg - 60 Capsules | Seeking Health SAMe by Seeking Health provides 250 mg of S-adenosyl-L-methionine (SAMe) per acid-resistant, vegetarian capsule.SAMe is a vulnerable nutrient. Many SAMe supplements on the market are unstable. We use acid-resistant capsules designed for optimal delivery of SAMe to the gut for absorption. To further optimize stability and prevent degradation, the capsules are protected from moisture and air in a desiccated bottle.SAMe (S-adenosylmethionine or S-adenosyl-L-methionine) is your body's main methyl donor. It is found in nearly every tissue and fluid. It is involved in hundreds of biochemical reactions in the human body. By providing your body methyl groups, SAMe plays vital roles in DNA expression, neurotransmitter and hormone balance, normal liver cell regeneration, and much more.SAMe aids in normal cartilage production, playing a major role in joint and bone health. SAMe is also an important part of histamine intolerance protocols. It is a cofactor for the HNMT enzyme which helps to break down histamine for healthy inflammatory responses and mast cell balance.SAMe is a nutrient cofactor for many important enzymatic reactions in the body, including the COMT enzyme. COMT helps you break down excess dopamine to support a healthy mood and feelings of calm.Because so many compounds and processes in your body depend upon methyl groups, SAMe is known to support many areas of health, such as: DNA expression Neurotransmitter synthesis & metabolism Hormone balance Bone & Joint health Liver function Positive mood & Cognitive function Cell membranes Energy production Methylation & Transsulfuration pathways Glutathione production Now you can support your mood, methylation, and more with SAMe by Seeking Health.